Drug discovery

Zebrafish Core Facility

Zebrafish (Danio Rerio) is a small freshwater fish that has gained increasing use as a scientific model organism during recent years. As a model organism, the genome of zebrafish can be easily modified using transgenesis and targeted mutagenesis. The externally developing eggs provide a convenient, economic and ethical model for various in vivo studies. As […]

Basic research, Disease models, Target discovery

Structural Bioinformatics Laboratory (SBL)

SBL places biological data within the three-dimensional molecular context, exploiting this knowledge to derive better understandings of biological processes, especially related to ligand binding and discovery of novel ligands. We combine data from many sources, public and project-generated, both experimental and in silico. SBL has a state-of-the-art crystallography laboratory, uses European synchrotron facilities for diffraction […]

Basic research, Hit to lead, Lead optimization

Industrial Physics Laboratory

The Industrial Physics Laboratory has over 30 years’ experience in pharmaceutical research in collaboration of national and international pharma companies. The laboratory is equipped with extensive thermoanalytical instrumentation (TG, DTA, SMA, DSC, isothermal microcalorimetry) and X-ray diffraction equipments. Other techniques include also a modern gas sorption apparatus (TriStar), FTIR, fluorescence spectrophotometry, dynamic light scattering and […]

Hit to lead, Lead optimization, Preclinical development

The Turku Proteomics Facility

The Turku Proteomics unit provides advanced proteomics services for academic researchers and industry for all Finland. We have a full range of state of the art mass spectrometers including Q-Exactive and Q-Exactive HF, Orbitrap Velos ETD, Orbitrap Lumos and a ThermoFisher triple quadrupole. We are the Finnish Proteomics methods development centre specialising in the analysis […]

Basic research, Biomarker, Drug target, Hit to lead, Lead optimization, Molecular diagnostics, Proteomics, Receptor, Signaling, Target discovery

Protein Crystallography Core Facility

Knowledge of protein structure is central to the understanding of biological processes in living organisms and cells.  The Protein Crystallography Core Facility assists investigators in the determination and analysis of the 3-dimensional structure of biological macromolecules and their complexes. The facility consists of an in-house X-ray generator and imaging plate detector, cryo-crystallography instrumentation, several computers, […]

Basic research, Hit to lead, Lead optimization, Molecular modelling, Signaling, Target discovery, X-ray crystallography

The Instrument Centre

The Instrument Centre serves as a shared facility for University of Turku and Åbo Akademi University. With five modern NMR (Nuclear Magnetic Resonance) instruments and a sophisticated mass spectrometer, the Centre is one of the best equipped educational NMR/MS facilities in Finland. Our main focus is in NMR spectroscopy and for the applications we have […]

Basic research, Hit to lead, Lead optimization, Metabolomics, NMR, Preclinical development