Research Groups and R&D Platforms: Lead optimization

Research Group:
BioNanoMaterials research group

Jessica Rosenholm
Jessica.rosenholm[at]abo.fi

Pharmaceutical Sciences Laboratory,
Åbo Akademi University

Jessica Rosenholm

Pharmaceutical Sciences Laboratory

 

Antibacterial, Biomedicine, Biopharmaceuticals, Biotechnology, Cancer, Diagnostics, Drug delivery, Drug solubility, Drug stability, Electron microscopy, Fluorescence spectroscopy, Formulation, FTIR or RAMAN spectroscopy, Imaging software, Infection, Lead optimization, Musculoskeletal disorders, Nanoparticles, Natural products, Organic compounds, Particle morphology, Particle size analysis, Personalized medicine, Pharmacy, Physico-chemical properties, Porosity, Powder flow characterization, Powder X-ray diffraction, Preclinical development, Screening, Skin diseases, Super-resolution imaging, Surface area, Synthetic chemistry, Thermal analysis, Zeta potential

Research Group:
Functional Biomaterials & Microfluids

Hongbo Zhang
hongbo.zhang[at]abo.fi

Pharmaceutical Sciences Laboratory,
Åbo Akademi University

Hongbo Zhang

Structural Bioinformatics Laboratory

Atomic-force microscopy, Bioinformatics, Biomarker, Biomedicine, Cancer, Cardiovascular diseases, Data mining, Drug delivery, Drug solubility, Drug stability, Drug target, Electron microscopy, Fluorescence spectroscopy, FTIR or RAMAN spectroscopy, Genetics, Genomics, High throughput imaging, Imaging, Imaging software, In Vivo Diagnostics, Lead optimization, Molecular diagnostics, Nanoparticles, Next-generation sequencing, NMR, Nucleic acids, Organic compounds, Particle morphology, Particle size analysis, Personalized medicine, PET, Physico-chemical properties, Polymorph analysis, Porosity, Screening, Super-resolution imaging, Surface area, Synthetic chemistry, Target discovery, Thermal analysis, Ultrasound imaging, X-ray crystallography, Zeta potential

Research Group:
Antibiotic Biosynthesis Engineering

Mikko Metsä-Ketelä
mianme[at]utu.fi

Department of Biochemistry,
University of Turku

Mikko Metsä-Ketelä

ABE Lab

Antibacterial, Bacteriology, Biochemistry, Bioinformatics, Biotechnology, Cancer, Hit to lead, Lead optimization, Molecular Biology, Natural Compounds, Natural products, Structural Biology, Synthetic Biology

Research Group:
Natural Chemistry Research Group

Juha-Pekka Salminen
j-p.salminen[at]utu.fi

Department of Chemistry,
University of Turku

Juha-Pekka Salminen

Natural Chemistry Research Group

Hit to lead, Lead optimization, Natural Compounds, Natural products

Research Group:
Computer-aided drug design

Outi Salo-Ahen
osalo[at]abo.fi

Pharmaceutical Sciences and Structural Bioinformatics Laboratory,
Åbo Akademi University

Outi Salo-Ahen

Computer-aided drug design

 

Antibacterial, Bioinformatics, Biomolecular chemistry, Biopharmaceuticals, Cancer, Drug target, Hit to lead, Infection, Lead optimization, Medicinal chemistry, Molecular modelling, Natural Compounds, Natural products, Pharmacy, Preclinical development, Screening, Structural Biology

R&D Platform:
Bioanalytical Laboratory

Pharmacokinetic assessments and documentation of drug exposure are essential elements of all drug discovery and development endeavours. This research project aims to provide a technology platform for joint projects with investigators working in various fields of drug discovery and development. An automated system enabling frequent blood sampling from freely moving small laboratory animals and modern analytic instrumentation based on liquid chromatography and tandem mass spectrometry form the essential elements of this platform. Recent examples of the laboratory’s output are exemplified by the publications listed below, but a significant fraction of the laboratory’s projects represents contract research for small drug discovery companies. It is expected that this technology platform will help to promote both academic and commercial drug discovery and development activities in Finland.

Bioanalytical Laboratory

Hit to lead, Lead optimization, Preclinical development