Research Groups and R&D Platforms: Lead optimization

Research Group:
Bio-Organic Chemistry

Tuomas Lönnberg

Department of Chemistry,
University of Turku

Bioorganic Group

Basic research, Biomolecular chemistry, Diagnostics, Fluorescence spectroscopy, Hit to lead, In Vitro Diagnostics, Lead optimization, NMR, Nucleic acids, Organic Chemistry, Organic compounds, Synthetic chemistry

Research Group:
Structural bioinformatics for drug discovery and development

Mark S. Johnson
finmark54 at icloud dot com

Åbo Akademi University

Ageing-related diseases, Autoimmune diseases, Basic research, Biochemistry, Bioinformatics, Biomolecular chemistry, Biopharmaceuticals, Biotechnology, Cancer, Chemical Physics, Computer Science, Diabetes, Drug target, Hit to lead, Inflammation, Inherited diseases, Lead optimization, Lung cancer, Medicinal chemistry, Metabolic diseases, Molecular modelling, Musculoskeletal disorders, Nucleic acids, Organic compounds, Pattern recognition, Personalized medicine, Physico-chemical properties, Preclinical development, Receptor, Signaling, Structural Biology, Surface area, Target discovery, X-ray crystallography

Research Group:
Systems Molecular Engineering

Jianwei Li[at]

Department of Chemistry,
University of Turku

Atomic-force microscopy, Basic research, Biochemistry, Biomarker, Biomedicine, Biomolecular chemistry, Biotechnology, Cancer, Chemical Physics, Combinatorial chemistry, Drug delivery, Drug target, Electron microscopy, Fluorescence spectroscopy, FTIR or RAMAN spectroscopy, Hit to lead, Imaging, Infection, Inflammation, Lead optimization, Medicinal chemistry, Microstructure analysis, Molecular modelling, Nanoparticles, Natural Compounds, Next-generation sequencing, NMR, Nucleic acids, Organic Chemistry, Organic compounds, Particle size analysis, Physico-chemical properties, Powder X-ray diffraction, Preclinical development, Proteomics, Screening, Structural Biology, Synthetic Biology, Synthetic chemistry, Thermal analysis, X-ray crystallography

Research Group:
Medicinal Chemistry

Olli Pentikäinen

Institute of Biomedicine,
University of Turku

Autoimmune diseases, Basic research, Bioinformatics, Biomedicine, Cancer, Hit to lead, Inflammation, Inherited diseases, Lead optimization, Medicinal chemistry, Molecular modelling, Organic compounds, Pharmacology, Physico-chemical properties, Receptor, Screening, Signaling, Structural Biology, Synthetic chemistry

R&D Platform:
Turku Center for Disease Modeling

TCDM is a research and research service organization at the Faculty of Medicine, University of Turku, and is part of the Biocenter Finland “Model Organisms” network. TCDM provides state-of-art research facilities and expertise in studies in experimental animals to support both academic and industrial associated preclinical research. The facilities and expertise are also available for contract research.

The services provided by TCDM are always tailored according to customer’s needs. TCDM generates tumor xenograft and genetically modified mouse models for human diseases. Services using the animal models include pharmacological, dietary and surgical interventions as well as phenotyping analyses on our expertise areas: bone, cardiovascular, intestinal and thyroid diseases, obesity, oncology, neuroendocrinology and reproduction. Phenotyping analyses offered include histology, immunohistochemistry and electron microscopy, hormonal measurements, in vivo imaging for live animals, for example PET/CT, magnetic resonance, ultrasound and optical imaging. For drug development TCDM services include several type of drug efficacy tests, pharmacokinetic analyses of drug compounds and in vivo biodistribution analyses using preclinical animal models. Moreover, TCDM Biostatistics unit offers know-how on the computational and mathematical analyses related to preclinical animal studies, including their experimental design and statistical analysis.


Cancer, Cardiovascular diseases, Disease models, Lead optimization, Obesity, Preclinical development

Research Group:
High Content Screening Laboratory

Matthias Nees (Principal Investigator)

Malin Åkerfelt (Contact person, in picture)

Institute of Biomedicine,
Univesity of Turku


Assay development, Bioinformatics, Biomedicine, Biotechnology, Breast cancer, Cancer, Disease models, Drug target, High throughput imaging, Hit to lead, Imaging, Inflammation, Lead optimization, Lung cancer, Machine learning, Molecular Cell Biology, Natural Compounds, Prostate cancer, Screening, Target discovery