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Main categories: Drug discovery
SBL places biological data within the three-dimensional molecular context, exploiting this knowledge to derive better understandings of biological processes, especially related to ligand binding and discovery of novel ligands. We combine data from many sources, public and project-generated, both experimental and in silico. SBL has a state-of-the-art crystallography laboratory, uses European synchrotron facilities for diffraction data collection, and solves structures in-house. SBL has extensive computational resources: software, molecular databases, graphic devices for 3D visualization, large-capacity data storage, computational clusters, and we make heavy use of CSC IT Center for Science supercomputing cloud resources for in silico ligand screening and molecular simulations. Our groups share space and infrastructure at SBL, providing a wealth of experience. The unit has responsibilities for Biocenter Finland infrastructures in (1) Bioinformatics, (2) Structural Biology, and (3) Drug Discovery and Chemical Biology, providing open-access to protein crystallization resources, scientific IT and bioinformatics services, hardware and software, and long-term project collaboration, available to everyone.
Our experience focuses on proteins and their interactions with natural and synthetic ligands, including proteins, nucleic acids, lipids and carbohydrates. Our researchers have a broad understanding of the sciences and relevant technologies.