Research Groups and R&D Platforms: Hit to lead

Research Group:
Antibiotic Biosynthesis Engineering

Mikko Metsä-Ketelä
mianme[at]utu.fi

Department of Biochemistry,
University of Turku

Mikko Metsä-Ketelä

ABE Lab

Antibacterial, Bacteriology, Biochemistry, Bioinformatics, Biotechnology, Cancer, Hit to lead, Lead optimization, Molecular Biology, Natural Compounds, Natural products, Structural Biology, Synthetic Biology

Research Group:
Protein Crystallography

Tassos Papageorgiou
tassos.papageorgiou[at]bioscience.fi

Turku Bioscience,
University of Turku and Åbo Akademi University

Tassos Papageorgiou

Protein Crystallography

Protein Structure and Chemistry

Cancer, Hit to lead, Infection, Molecular modelling, Neurological disorders, Signaling, Structural Biology, Target discovery, X-ray crystallography

Research Group:
Natural Chemistry Research Group

Juha-Pekka Salminen
j-p.salminen[at]utu.fi

Department of Chemistry,
University of Turku

Juha-Pekka Salminen

Natural Chemistry Research Group

Hit to lead, Lead optimization, Natural Compounds, Natural products

Research Group:
Computer-aided drug design

Outi Salo-Ahen
osalo[at]abo.fi

Pharmaceutical Sciences and Structural Bioinformatics Laboratory,
Åbo Akademi University

Outi Salo-Ahen

Computer-aided drug design

 

Antibacterial, Bioinformatics, Biomolecular chemistry, Biopharmaceuticals, Cancer, Drug target, Hit to lead, Infection, Lead optimization, Medicinal chemistry, Molecular modelling, Natural Compounds, Natural products, Pharmacy, Preclinical development, Screening, Structural Biology

R&D Platform:
Bioanalytical Laboratory

Pharmacokinetic assessments and documentation of drug exposure are essential elements of all drug discovery and development endeavours. This research project aims to provide a technology platform for joint projects with investigators working in various fields of drug discovery and development. An automated system enabling frequent blood sampling from freely moving small laboratory animals and modern analytic instrumentation based on liquid chromatography and tandem mass spectrometry form the essential elements of this platform. Recent examples of the laboratory’s output are exemplified by the publications listed below, but a significant fraction of the laboratory’s projects represents contract research for small drug discovery companies. It is expected that this technology platform will help to promote both academic and commercial drug discovery and development activities in Finland.

Bioanalytical Laboratory

Hit to lead, Lead optimization, Preclinical development

Research Group:
Valorisation of biomass using molecular process technology

Stefan Willför
swillfor[at]abo.fi

Laboratory of Wood and Paper Chemistry,
Åbo Akademi University

Stefan Willför

PCC

Antibacterial, Biopharmaceuticals, Diagnostics, Drug solubility, Drug stability, Electron microscopy, Hit to lead, MALS or SEC-MALS, Natural Compounds, Natural products, NMR, Organic Chemistry, Organic compounds, Particle size analysis, Personalized medicine, Physico-chemical properties, Porosity, Surface area, Synthetic chemistry, Thermal analysis