Research Groups and R&D Platforms: Hit to lead
Research Group:
Antibiotic Biosynthesis Engineering
Mikko Metsä-Ketelä
mianme[at]utu.fi
Department of Life Technologies,
University of Turku
Antibacterial, Bacteriology, Biochemistry, Bioinformatics, Biotechnology, Cancer, Hit to lead, Lead optimization, Molecular Biology, Natural Compounds, Natural products, Structural Biology, Synthetic Biology
Research Group:
Protein Crystallography
Tassos Papageorgiou
tassos.papageorgiou[at]bioscience.fi
Turku Bioscience Centre,
University of Turku and Åbo Akademi University
Protein Structure and Chemistry
Cancer, Hit to lead, Infection, Molecular modelling, Neurological disorders, Signaling, Structural Biology, Target discovery, X-ray crystallography
Research Group:
Natural Chemistry Research Group
Juha-Pekka Salminen
j-p.salminen[at]utu.fi
Department of Chemistry,
University of Turku
Natural Chemistry Research Group
Hit to lead, Lead optimization, Natural Compounds, Natural products
Research Group:
Computer-aided drug design
Outi Salo-Ahen
osalo[at]abo.fi
Pharmaceutical Sciences and Structural Bioinformatics Laboratory,
Åbo Akademi University
Antibacterial, Bioinformatics, Biomolecular chemistry, Biopharmaceuticals, Cancer, Drug target, Hit to lead, Infection, Lead optimization, Medicinal chemistry, Molecular modelling, Natural Compounds, Natural products, Pharmacy, Preclinical development, Screening, Structural Biology
R&D Platform:
Bioanalytical Laboratory
Pharmacokinetic assessments and documentation of drug exposure are essential elements of all drug discovery and development endeavours. This research project aims to provide a technology platform for joint projects with investigators working in various fields of drug discovery and development. An automated system enabling frequent blood sampling from freely moving small laboratory animals and modern analytic instrumentation based on liquid chromatography and tandem mass spectrometry form the essential elements of this platform. Recent examples of the laboratory’s output are exemplified by the publications listed below, but a significant fraction of the laboratory’s projects represents contract research for small drug discovery companies. It is expected that this technology platform will help to promote both academic and commercial drug discovery and development activities in Finland.
Hit to lead, Lead optimization, Preclinical development
Research Group:
Valorisation of biomass using molecular process technology
Stefan Willför
swillfor[at]abo.fi
Laboratory of Wood and Paper Chemistry,
Åbo Akademi University
Antibacterial, Biopharmaceuticals, Diagnostics, Drug solubility, Drug stability, Electron microscopy, Hit to lead, MALS or SEC-MALS, Natural Compounds, Natural products, NMR, Organic Chemistry, Organic compounds, Particle size analysis, Personalized medicine, Physico-chemical properties, Porosity, Surface area, Synthetic chemistry, Thermal analysis
