Research Groups and R&D Platforms: Bioinformatics
Research Group:
High Content Screening Laboratory
Matthias Nees (Principal Investigator)
Malin Åkerfelt (Contact person, in picture)
malake[at]utu.fi
Institute of Biomedicine,
Univesity of Turku
Assay development, Bioinformatics, Biomedicine, Biotechnology, Breast cancer, Cancer, Disease models, Drug target, High throughput imaging, Hit to lead, Imaging, Inflammation, Lead optimization, Lung cancer, Machine learning, Molecular Cell Biology, Natural Compounds, Prostate cancer, Screening, Target discovery
Research Group:
Molecular epidemiology, carriage and antimicrobial susceptibility of bacterial pathogens
Jaana Vuopio
jaana.vuopio[at]utu.fi
Institute of Biomedicine,
University of Turku
Antibacterial, Antibodies, Bacteriology, Basic research, Bioinformatics, Biomarker, Biomedicine, Clinical Medicine, Data mining, Diagnostics, Epidemiology, Genetics, Genomics, Immunology, In Vitro Diagnostics, In Vivo Diagnostics, Infection, Inflammation, Molecular diagnostics, Next-generation sequencing, Nucleic acids, Personalized medicine, Point of care, Receptor
Research Group:
Medicinal Chemistry
Olli Pentikäinen
olli.pentikainen[at]utu.fi
Institute of Biomedicine,
University of Turku
Autoimmune diseases, Basic research, Bioinformatics, Biomedicine, Cancer, Hit to lead, Inflammation, Inherited diseases, Lead optimization, Medicinal chemistry, Molecular modelling, Organic compounds, Pharmacology, Physico-chemical properties, Receptor, Screening, Signaling, Structural Biology, Synthetic chemistry
Research Group:
Structural bioinformatics for drug discovery and development
Mark S. Johnson
finmark54 at icloud dot com
Biochemistry,
Åbo Akademi University
Structural Bioinformatics Laboratory
Ageing-related diseases, Autoimmune diseases, Basic research, Biochemistry, Bioinformatics, Biomolecular chemistry, Biopharmaceuticals, Biotechnology, Cancer, Chemical Physics, Computer Science, Diabetes, Drug target, Hit to lead, Inflammation, Inherited diseases, Lead optimization, Lung cancer, Medicinal chemistry, Metabolic diseases, Molecular modelling, Musculoskeletal disorders, Nucleic acids, Organic compounds, Pattern recognition, Personalized medicine, Physico-chemical properties, Preclinical development, Receptor, Signaling, Structural Biology, Surface area, Target discovery, X-ray crystallography
Research Group:
Molecular mechanisms of diseases
Ulla Pentikäinen
ulla.pentikainen[at]utu.fi
Institute of Biomedicine,
University of Turku
Basic research, Bioinformatics, Biomedicine, Biomolecular chemistry, Cancer, Cardiovascular diseases, Developmental disorders, Medicinal chemistry, Molecular modelling, NMR, Structural Biology, Target discovery, X-ray crystallography
R&D Platform:
Turku Metabolomics Centre
The Turku Metabolomics Centre (TMC) was established in the Fall of 2017, and currently comprises four analytical laboratories on the University of Turku and Åbo Academy campuses, with the primary focus on biomedical and clinical applications. TMC covers a broad range of analytical methods, useful for discovery studies, hypothesis-driven targeted studies as well as clinical applications in Good Laboratory Practice (GLP) setting. The methods include:
1. Targeted quantitative analyses by mass spectrometry (MS) of specific groups of metabolites, e.g. bile acids, endocannabinoids, amino acids, eicosanoids.
2. Global profiling of molecular lipids (lipidomics) and polar metabolites.
3. Diagnostic, drug metabolism and pharmacokinetic applications in Good Laboratory Practice (GLP) setting.
4. Tissue metabolomics by Nuclear Magnetic Resonance (NMR).
5. How dietary intake affects blood metabolism.
TMC infrastructure currently includes 7 MS instruments (2 x UHPLC-QTRAP/QqQ-MS, 2 x UHPLC-QqQ-MS, 1 x GC-QqQ-MS, 2 x GC-QMS) and 2 NMR instruments (1 x 600 MHz and 1 x 400 MHz). The 400 MHz spectrometer is equipped with a high resolution magic angle spinning probe for the detection of metabolites in tissue and cell samples without the need for extensive sample preparation. The 600MHz instrument is equipped with a cooled sample handling robot with space for 300 samples allowing high throughput liquid NMR studies. Two new MS instruments also being purchased this year.
Basic research, Bioinformatics, Diagnostics, In Vitro Diagnostics, Machine learning, Metabolomics, NMR, Pattern recognition, R&D Platforms, Systems Biology, Target discovery
