Research Groups and R&D Platforms: Lead optimization
Research Group:
Bio-Organic Chemistry
Tuomas Lönnberg
tuanlo[at]utu.fi
Department of Chemistry,
University of Turku
Basic research, Biomolecular chemistry, Diagnostics, Fluorescence spectroscopy, Hit to lead, In Vitro Diagnostics, Lead optimization, NMR, Nucleic acids, Organic Chemistry, Organic compounds, Synthetic chemistry
R&D Platform:
Screening Unit
The screening unit offers academic researchers and industrial customers a broad range of services for identifying and optimising bioactive molecules for the drug discovery process. These include molecular modelling and in silico screening, development of screening assays and compound library screens, in vitro and in situ hit validation, hit optimisation and SAR analyses. A suite of cell and tissue-based disease models for oncology and neurological diseases are available for further validation of optimised hits or for independent phenotypic screens. High-throughput kinetic assays of changes in morphology or intracellular signalling over time may be integrated into chemical, genetic or optogenetic perturbation screens. A library of reporters in gene-delivery vectors are available for this purpose. The unit also has experience performing screens and toxicological evaluations in small animal models.
Contact details
High-throughput screens, screen-compatible assays, high-throughput microscopy, libraries, optogenetics, cell-based neurological disease models:
michael.courtney[at]utu.fi
3D oncology models, phenotypic screens, high-content screens:
malin.akerfelt[at]utu.fi
Medicinal chemistry, virtual screening and molecular modelling:
olli.pentikainen[at]utu.fi
Assay development, Basic research, Disease models, High throughput imaging, Hit to lead, Lead optimization, Medicinal chemistry, Molecular modelling, R&D Platforms, Screening, Signaling, Target discovery
Research Group:
Recombinant antibodies and other bioaffinity molecules
Urpo Lamminmäki
urplammi[at]utu.fi
Department of Life Technologies,
University of Turku
Antibodies, Assay development, Basic research, Biomarker, Biotechnology, Cancer, Combinatorial chemistry, Diagnostics, Drug target, Fluorescence spectroscopy, Hit to lead, In Vitro Diagnostics, Infection, Lead optimization, Metabolic diseases, Molecular Biology, Molecular modelling, Nanoparticles, Next-generation sequencing, Ovarian cancer, Point of care, Prostate cancer, Screening, Synthetic Biology, Target discovery
