Research Groups and R&D Platforms: Lead optimization
Research Group:
BioNanoMaterials research group
Jessica Rosenholm
Jessica.rosenholm[at]abo.fi
Pharmaceutical Sciences Laboratory,
Åbo Akademi University
Pharmaceutical Sciences Laboratory
Antibacterial, Biomedicine, Biopharmaceuticals, Biotechnology, Cancer, Diagnostics, Drug delivery, Drug solubility, Drug stability, Electron microscopy, Fluorescence spectroscopy, Formulation, FTIR or RAMAN spectroscopy, Imaging software, Infection, Lead optimization, Musculoskeletal disorders, Nanoparticles, Natural products, Organic compounds, Particle morphology, Particle size analysis, Personalized medicine, Pharmacy, Physico-chemical properties, Porosity, Powder flow characterization, Powder X-ray diffraction, Preclinical development, Screening, Skin diseases, Super-resolution imaging, Surface area, Synthetic chemistry, Thermal analysis, Zeta potential
Research Group:
Functional Biomaterials & Microfluids
Hongbo Zhang
hongbo.zhang[at]abo.fi
Pharmaceutical Sciences Laboratory,
Åbo Akademi University
Structural Bioinformatics Laboratory
Atomic-force microscopy, Bioinformatics, Biomarker, Biomedicine, Cancer, Cardiovascular diseases, Data mining, Drug delivery, Drug solubility, Drug stability, Drug target, Electron microscopy, Fluorescence spectroscopy, FTIR or RAMAN spectroscopy, Genetics, Genomics, High throughput imaging, Imaging, Imaging software, In Vivo Diagnostics, Lead optimization, Molecular diagnostics, Nanoparticles, Next-generation sequencing, NMR, Nucleic acids, Organic compounds, Particle morphology, Particle size analysis, Personalized medicine, PET, Physico-chemical properties, Polymorph analysis, Porosity, Screening, Super-resolution imaging, Surface area, Synthetic chemistry, Target discovery, Thermal analysis, Ultrasound imaging, X-ray crystallography, Zeta potential
Research Group:
Antibiotic Biosynthesis Engineering
Mikko Metsä-Ketelä
mianme[at]utu.fi
Department of Life Technologies,
University of Turku
Antibacterial, Bacteriology, Biochemistry, Bioinformatics, Biotechnology, Cancer, Hit to lead, Lead optimization, Molecular Biology, Natural Compounds, Natural products, Structural Biology, Synthetic Biology
Research Group:
Natural Chemistry Research Group
Juha-Pekka Salminen
j-p.salminen[at]utu.fi
Department of Chemistry,
University of Turku
Natural Chemistry Research Group
Hit to lead, Lead optimization, Natural Compounds, Natural products
Research Group:
Computer-aided drug design
Outi Salo-Ahen
osalo[at]abo.fi
Pharmaceutical Sciences and Structural Bioinformatics Laboratory,
Åbo Akademi University
Antibacterial, Bioinformatics, Biomolecular chemistry, Biopharmaceuticals, Cancer, Drug target, Hit to lead, Infection, Lead optimization, Medicinal chemistry, Molecular modelling, Natural Compounds, Natural products, Pharmacy, Preclinical development, Screening, Structural Biology
R&D Platform:
Bioanalytical Laboratory
Pharmacokinetic assessments and documentation of drug exposure are essential elements of all drug discovery and development endeavours. This research project aims to provide a technology platform for joint projects with investigators working in various fields of drug discovery and development. An automated system enabling frequent blood sampling from freely moving small laboratory animals and modern analytic instrumentation based on liquid chromatography and tandem mass spectrometry form the essential elements of this platform. Recent examples of the laboratory’s output are exemplified by the publications listed below, but a significant fraction of the laboratory’s projects represents contract research for small drug discovery companies. It is expected that this technology platform will help to promote both academic and commercial drug discovery and development activities in Finland.
Hit to lead, Lead optimization, Preclinical development
