Research Groups and R&D Platforms: Cancer
R&D Platform:
Turku Center for Disease Modeling
TCDM is a research and research service organization at the Faculty of Medicine, University of Turku, and is part of the Biocenter Finland “Model Organisms” network. TCDM provides state-of-art research facilities and expertise in studies in experimental animals to support both academic and industrial associated preclinical research. The facilities and expertise are also available for contract research.
The services provided by TCDM are always tailored according to customer’s needs. TCDM generates tumor xenograft and genetically modified mouse models for human diseases. Services using the animal models include pharmacological, dietary and surgical interventions as well as phenotyping analyses on our expertise areas: bone, cardiovascular, intestinal and thyroid diseases, obesity, oncology, neuroendocrinology and reproduction. Phenotyping analyses offered include histology, immunohistochemistry and electron microscopy, hormonal measurements, in vivo imaging for live animals, for example PET/CT, magnetic resonance, ultrasound and optical imaging. For drug development TCDM services include several type of drug efficacy tests, pharmacokinetic analyses of drug compounds and in vivo biodistribution analyses using preclinical animal models. Moreover, TCDM Biostatistics unit offers know-how on the computational and mathematical analyses related to preclinical animal studies, including their experimental design and statistical analysis.
Cancer, Cardiovascular diseases, Disease models, Lead optimization, Obesity, Preclinical development
R&D Platform:
Turku PET Centre
Turku PET Centre is a Finnish National Research Institute for the use of short-lived positron emitting isotopes in the field of medical research.
The scientific research strategy of the Turku PET Centre involves six major topics: Cardiovascular and Metabolic research, Brain research, Cancer research, Preclinical studies and Drug development, Radiochemistry research and Data processing and image analysis.
Collaboration between academia and industry is also active. The studies are carried out together with basic scientists, dedicated physicists and radiochemists, experienced clinical investigators and other professionals.
Cancer, Cardiovascular diseases, Clinical development, Diabetes, In Vivo Diagnostics, Obesity, PET, Preclinical development
Research Group:
Heat Shock Response Goes Beyond Cell Stress
Lea Sistonen
lea.sistonen[at]abo.fi
Department of Biosciences
Åbo Akademi University
Ageing-related diseases, Basic research, Biomarker, Biomedicine, Breast cancer, Cancer, Data mining, Disease models, Epigenomics, Genomics, Imaging, Molecular Biology, Molecular Cell Biology, Neurological disorders, Prostate cancer, Proteomics, Signaling, Target discovery
Research Group:
Laboratory of Biophysics
Pekka Hänninen
pekka.e.hanninen[at]utu.fi
Institute of Biomedicine,
University of Turku
Assay development, Atomic-force microscopy, Biomolecular chemistry, Cancer, Data mining, Diabetes, Diagnostics, Fluorescence spectroscopy, Imaging, In Vitro Diagnostics, Machine learning, Nanoparticles, Physics, Super-resolution imaging
Research Group:
Leukocyte traffic and the immune response
Marko Salmi
marko.salmi[at]utu.fi
Institute of Biomedicine
University of Turku
Autoimmune diseases, Basic research, Biomarker, Biomedicine, Cancer, Cardiovascular diseases, Imaging, Immunology, Inflammation, Next-generation sequencing, Receptor, Screening, Target discovery
Research Group:
Medicinal Chemistry
Olli Pentikäinen
olli.pentikainen[at]utu.fi
Institute of Biomedicine,
University of Turku
Autoimmune diseases, Basic research, Bioinformatics, Biomedicine, Cancer, Hit to lead, Inflammation, Inherited diseases, Lead optimization, Medicinal chemistry, Molecular modelling, Organic compounds, Pharmacology, Physico-chemical properties, Receptor, Screening, Signaling, Structural Biology, Synthetic chemistry
