Research Groups and R&D Platforms: Biomarker
Research Group:
Oxygen sensing mechnisms in renal cell cancer
Panu Jaakkola
panjaa[at]utu.fi
Turku University Hospital Cancer Centre
Biomarker, Biomedicine, Cancer, Clinical Medicine, Data mining, Diagnostics, Electron microscopy, Molecular diagnostics, Personalized medicine, Proteomics
Research Group:
Skin cancer and proteinase research group
Veli-Matti Kähäri
veli-matti.kahari[at]utu.fi
Department of Clinical Medicine,
University of Turku
Basic research, Biomarker, Clinical Medicine, Data mining, Diagnostics, Disease models, Drug target, In Vivo Diagnostics, Melanoma, Molecular Cell Biology, Molecular diagnostics, Next-generation sequencing, Nucleic acids, Pathology, Personalized medicine, Receptor, Signaling, Skin diseases, Squamous cell carcinoma, Target discovery
R&D Platform:
Medical Bioinformatics Centre
Medical Bioinformatics Centre focuses on the analysis of high-throughput data produced by modern biotechnologies, such as next-generation sequencing and mass spectrometry. The Unit has strong expertise in analysing and interpreting molecular data and it constantly strives for developing new data analysis methods and workflows to support cutting edge research in biology and medicine.
A specific focus of the research at the Unit is on biomedical applications in close collaboration with experimental and clinical groups. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases, such as diabetes and cancer, by combining computational, experimental and clinical expertise.
Medical Bioinformatics Centre provides support and services for the analysis of genomics, transcriptomics, epigenomics and proteomics data. The personnel of the Unit consist of more than 20 specialists with expertise in the various fields of bioinformatics and computational biology.
Our services
- Experimental design consultation
- Data analysis of various data types produced by high-throughput biotechnology instruments (e.g. microarrays, next-generation sequencing, mass spectrometry)
Data analysis service package
- Support for experimental design
- Data analysis with state-of-the-art bioinformatics software and in-house tools, including preprocessing, quality assessment, statistical analysis, functional/pathway analysis, and result visualization
- Results with comprehensive analysis report
- Result meeting
- Submission of data to public repository
Basic research, Biomarker, Data mining, Genomics, Hit to lead, Machine learning, Molecular diagnostics, Next-generation sequencing, Pattern recognition, Personalized medicine, Proteomics, Target discovery
R&D Platform:
The Turku Proteomics Facility
The Turku Proteomics unit provides advanced proteomics services for academic researchers and industry for all Finland. We have a full range of state of the art mass spectrometers including Q-Exactive and Q-Exactive HF, Orbitrap Velos ETD, Orbitrap Lumos and a ThermoFisher triple quadrupole. We are the Finnish Proteomics methods development centre specialising in the analysis of Post-Translational Modifications (phosphorylation, N-glycosylation, palmitoylation amongst others) as well as quantification methods (targeted SRM, PRM and DIA/SWATH
We provide a full service for samples (from sample preparation to MS data collection and protein identification and quantification) as well as an open access platform whereby customers who have completed a user course can run their own samples. Most quantification methods are available include label-free, TMT, iTRAQ, SILAC and AQUA. We also provide a direct interface with the Turku Bioinformatics unit allowing seamless statistical evaluation of data.
We have special focus areas of research including biomarker discovery and validation for the clinic and membrane protein analysis. We are developing protocols for small molecule analysis in tissues and serum as well as intact protein-ligand binding monitoring.
Basic research, Biomarker, Drug target, Hit to lead, Lead optimization, Molecular diagnostics, Proteomics, Receptor, Signaling, Target discovery
Research Group:
Preclinical Imaging
Tove Grönroos
tovgro[at]utu.fi
Turku PET Centre,
University of Turku
Biomarker, Biomedicine, Breast cancer, Cancer, Clinical Medicine, Disease models, Drug target, Imaging, In Vivo Diagnostics, Inflammation, Metabolic diseases, Molecular Biology, PET, Physiology, Preclinical development, Prostate cancer, Squamous cell carcinoma
Research Group:
Mechanisms of steroid hormone action
Matti Poutanen
matti.poutanen[at]utu.fi
Institute of Biomedicine,
University of Turku
Basic research, Biochemistry, Bioinformatics, Biomarker, Biomedicine, Breast cancer, Cancer, Data mining, Disease models, Drug delivery, Endocrinology, Genomics, Imaging, In Vitro Diagnostics, Machine learning, Metabolic diseases, Molecular Biology, Molecular Cell Biology, Next-generation sequencing, Obesity, Ovarian cancer, Pathology, Pharmacology, Physiology, Preclinical development, Prostate cancer, Proteomics, Receptor, Reproductive Medicine, Signaling, Systems Biology, Target discovery
