Research Groups and R&D Platforms: Preclinical development

Research Group:
Incretin-based therapy in preclinical and early clinical type 1 diabetes

Jorma Toppari
jorma.toppari[at]utu.fi

Institute of Biomedicine,
University of Turku

Department of Pediatrics,
Turku University Hospital

Jorma Toppari

On-going trials

Clinical development, Diabetes, Preclinical development

Research Group:
Complex Reaction Kinetics and Thermodynamics

Dmitry Murzin
dmurzin[at]abo.fi

Industrial Chemistry and Reaction Engineering,
Åbo Akademi University

Dmitry Murzin

Basic research, Cancer, Lead optimization, Medicinal chemistry, Nanoparticles, Natural products, Neurological disorders, Organic compounds, Physico-chemical properties, Porosity, Preclinical development, Surface area, Synthetic chemistry, Zeta potential

R&D Platform:
The Instrument Centre

The Instrument Centre serves as a shared facility for University of Turku and Åbo Akademi University. With five modern NMR (Nuclear Magnetic Resonance) instruments and a sophisticated mass spectrometer, the Centre is one of the best equipped educational NMR/MS facilities in Finland. Our main focus is in NMR spectroscopy and for the applications we have 400, 3 x 500 and 600 MHz Bruker Avance III spectrometers. The instrumentation was completely updated during 2016. Two of the instruments are equipped with Prodigy cryoprobe systems to enhance the sensitivity of the measurements significantly. In addition, our 400 MHz instrument is equipped with two solid state probes which enable the experiments with solid (CP-MAS) and semisolid (HR-MAS) materials. Three instruments are situated in building Arcanum (UTU) and two in Axelia (ÅAU).

Our own research covers all aspects of NMR applications. However, the main focus is on NMR metabolomics research of biological samples. The Instrument Centre offers also services for non-academic users. For more information, please visit at our webpage: instrumentcentre.utu.fi.

Basic research, Hit to lead, Lead optimization, Metabolomics, NMR, Preclinical development

Research Group:
Preclinical Imaging

Tove Grönroos
tovgro[at]utu.fi

Turku PET Centre,
University of Turku

Tove Grönroos

www.pet.fi

Biomarker, Biomedicine, Breast cancer, Cancer, Clinical Medicine, Disease models, Drug target, Imaging, In Vivo Diagnostics, Inflammation, Metabolic diseases, Molecular Biology, PET, Physiology, Preclinical development, Prostate cancer, Squamous cell carcinoma

Research Group:
Mechanisms of steroid hormone action

Matti Poutanen
matti.poutanen[at]utu.fi

Institute of Biomedicine,
University of Turku

Matti Poutanen

TCDM Matti Poutanen

Basic research, Biochemistry, Bioinformatics, Biomarker, Biomedicine, Breast cancer, Cancer, Data mining, Disease models, Drug delivery, Endocrinology, Genomics, Imaging, In Vitro Diagnostics, Machine learning, Metabolic diseases, Molecular Biology, Molecular Cell Biology, Next-generation sequencing, Obesity, Ovarian cancer, Pathology, Pharmacology, Physiology, Preclinical development, Prostate cancer, Proteomics, Receptor, Reproductive Medicine, Signaling, Systems Biology, Target discovery

R&D Platform:
Industrial Physics Laboratory

The Industrial Physics Laboratory has over 30 years’ experience in pharmaceutical research in collaboration of national and international pharma companies. The laboratory is equipped with extensive thermoanalytical instrumentation (TG, DTA, SMA, DSC, isothermal microcalorimetry) and X-ray diffraction equipments. Other techniques include also a modern gas sorption apparatus (TriStar), FTIR, fluorescence spectrophotometry, dynamic light scattering and zeta potential measurement instrument as well as access to surface analytical instruments such as TOF-SIMS, HR-SEM, and XPS.

The common research services laboratory have provided include stability and compatibility studies of pharmaceutical formulation, determination of surface amorphicity and crystal polymorphism studies. The main academic research topic of the laboratory is mesoporous drug delivering materials, which has been studied since 2004.  In addition, the electrostatics of powders has studied in the laboratory for almost 20 years already including a number of consultant services to industry.

The Industrial Physics Laboratory

Hit to lead, Lead optimization, Preclinical development