Research Groups and R&D Platforms: Preclinical development

R&D Platform:
Materials Research Laboratory

Materials Research Laboratory consists of two research groups, Materials Science (Prof. Edwin Kukk) and Materials Physics (Prof. Kalevi Kokko), focusing on both fundamental and applied physics. The interdisciplinary research combines experimental, computational, and theoretical investigations on, for example, organic molecules, semiconductors and other electronic materials, interfaces and surfaces of various systems, metal clusters and metal alloys with aim to better understand the physical and chemical phenomena and to develop materials for new technologies. National and international collaboration with other departments, universities and companies is an important part of our research.

The experiments are performed both at home laboratory and synchrotron facilities around the world. Electronic, chemical and structural  properties of different type of materials are studied combining several spectroscopic and microscopic methods like Time-of-flight/mass spectroscopy (TOF/MS), Photoelectron or Auger electron spectroscopy (XPS/AES) , Scanning tunneling microscopy (STM) and Electron diffraction (LEED) together with computational material physics. The know-how on development of new materials (e.g., surface passivation coatings) for electronic industry applications is strongly related to the thin film growth by using home-build atomic layer deposition equipment. We also design and build research instruments like electron-ion coincidence spectrometers or cluster sources to be used in gas-phase studies of molecules and clusters.

Materials Research Laboratory

Lead optimization, Preclinical development

R&D Platform:
Turku Center for Disease Modeling

TCDM is a research and research service organization at the Faculty of Medicine, University of Turku, and is part of the Biocenter Finland “Model Organisms” network. TCDM provides state-of-art research facilities and expertise in studies in experimental animals to support both academic and industrial associated preclinical research. The facilities and expertise are also available for contract research.

The services provided by TCDM are always tailored according to customer’s needs. TCDM generates tumor xenograft and genetically modified mouse models for human diseases. Services using the animal models include pharmacological, dietary and surgical interventions as well as phenotyping analyses on our expertise areas: bone, cardiovascular, intestinal and thyroid diseases, obesity, oncology, neuroendocrinology and reproduction. Phenotyping analyses offered include histology, immunohistochemistry and electron microscopy, hormonal measurements, in vivo imaging for live animals, for example PET/CT, magnetic resonance, ultrasound and optical imaging. For drug development TCDM services include several type of drug efficacy tests, pharmacokinetic analyses of drug compounds and in vivo biodistribution analyses using preclinical animal models. Moreover, TCDM Biostatistics unit offers know-how on the computational and mathematical analyses related to preclinical animal studies, including their experimental design and statistical analysis.

TCDM

Cancer, Cardiovascular diseases, Disease models, Lead optimization, Obesity, Preclinical development

R&D Platform:
Turku PET Centre

Turku PET Centre is a Finnish National Research Institute for the use of short-lived positron emitting isotopes in the field of medical research.

The scientific research strategy of the Turku PET Centre involves six major topics: Cardiovascular and Metabolic research, Brain research, Cancer research, Preclinical studies and Drug development, Radiochemistry research and Data processing and image analysis.

Collaboration between academia and industry is also active. The studies are carried out together with basic scientists, dedicated physicists and radiochemists, experienced clinical investigators and other professionals.

Turku PET Centre

Cancer, Cardiovascular diseases, Clinical development, Diabetes, In Vivo Diagnostics, Obesity, PET, Preclinical development

Research Group:
PET imaging of neuropathological changes in animal models of Alzheimer’s disease

Merja Haaparanta-Solin
mehaaso[at]utu.fi

Turku PET Centre, Preclinical Imaging,
University of Turku

Merja Haaparanta-Solin

Turku PET Centre

Ageing-related diseases, Antibodies, Autoimmune diseases, Basic research, Biochemistry, Biomarker, Biomedicine, Cardiovascular diseases, Diabetes, Disease models, Drug target, Imaging, In Vitro Diagnostics, In Vivo Diagnostics, Inflammation, Metabolic diseases, Nanoparticles, Neurological disorders, Organic compounds, PET, Pharmacology, Preclinical development, Receptor, Target discovery

Research Group:
Imaging Alzheimer’s disease beta-amyloid pathology in transgenic mouse models using positron emission tomography

Francisco López-Picón
fralop[at]utu.fi

Turku PET Centre, Preclinical Imaging,
University of Turku

Francisco López-Picón

Turku PET Centre

Ageing-related diseases, Biomarker, Biomedicine, Biopharmaceuticals, Clinical Medicine, Disease models, Drug delivery, Drug target, Epigenomics, Imaging, Imaging software, In Vitro Diagnostics, In Vivo Diagnostics, Inflammation, Molecular Biology, Molecular diagnostics, Neurological disorders, Pathology, PET, Pharmacology, Physiology, Preclinical development, Proteomics, Target discovery

Research Group:
Systems Molecular Engineering

Jianwei Li
jianwei.li[at]utu.fi

Department of Chemistry,
University of Turku

Jianwei Li

Jianwei Li Research Group

Atomic-force microscopy, Basic research, Biochemistry, Biomarker, Biomedicine, Biomolecular chemistry, Biotechnology, Cancer, Chemical Physics, Combinatorial chemistry, Drug delivery, Drug target, Electron microscopy, Fluorescence spectroscopy, FTIR or RAMAN spectroscopy, Hit to lead, Imaging, Infection, Inflammation, Lead optimization, Medicinal chemistry, Microstructure analysis, Molecular modelling, Nanoparticles, Natural Compounds, Next-generation sequencing, NMR, Nucleic acids, Organic Chemistry, Organic compounds, Particle size analysis, Physico-chemical properties, Powder X-ray diffraction, Preclinical development, Proteomics, Screening, Structural Biology, Synthetic Biology, Synthetic chemistry, Thermal analysis, X-ray crystallography